{"id":1575,"date":"2016-10-05T13:34:48","date_gmt":"2016-10-05T10:34:48","guid":{"rendered":"https:\/\/www.womansprevention.gr\/en\/aptima-hpv-stochevontas-ton-kindyno\/"},"modified":"2016-10-07T15:23:31","modified_gmt":"2016-10-07T12:23:31","slug":"aptima-hpv-test-aiming-at-risk","status":"publish","type":"page","link":"https:\/\/www.womansprevention.gr\/en\/aptima-hpv-test-aiming-at-risk\/","title":{"rendered":"Aptima HPV Test – Aiming at risk"},"content":{"rendered":"

Aptima HPV Test for high risk types and Aptima HPV 16 18\/45 detect the presence of an active HPV infection, which may cause cervical cancer.\u00a0\u00a0Almost all women and men will come in contact with the virus at some point in their life. However, very few will suffer from the infection or will have cancer 1<\/sup>.\u00a0Aptima HPV Test detects oncogenes \u03956\/\u03957 of the oncogenic mRNA HPV types 2<\/sup>. The expression of\u00a0 mRNA proteins \u03956\/\u03957 indicates that the virus infection will lead to the disease 2,3<\/sup>.<\/p>\n

\"aptima-hpv-test\"<\/p>\n

Since HPV DNA levels may be reduced while the infection becomes cancer, some HPV DNA tests give false negative results in more than 10% of serious cervical lesions 4<\/sup>.<\/p>\n

\n

\u2015 Aptima HPV test design<\/strong><\/p>\n

Aptima HPV Test, by detecting areas \u03956\/\u03957 of the virus mRNA aims at the oncogenic action of the virus 5<\/sup>.<\/p>\n

Tests aiming at L1 virus area, aim only at one area, which is not a necessary factor to the progress of the disease and which may disappear during the virus integration 9<\/sup>. There is up to 10-15% risk that some serious cases of the disease are not\u00a0detected, if a test based only on L1 area detection is used 6-8<\/sup>.<\/p>\n

\"aptimahpv\"<\/p>\n

\n

\u2015 During Integration L1 area may be deleted <\/strong><\/p>\n

Aptima HPV Test is as sensitive as an HPV DNA Test. High sensitivity minimizes false negative results. At the same moment, Aptima HPV Test\u00a0 offers high specificity. In other words, it reduces false positive results, therefore, meaningless therapeutic interventions.\u00a0 Aptima HPV Test gave 24% less false negative results than a HPV DNA test 5<\/sup>.<\/p>\n

\"thinprep4\"<\/p>\n

\"aptrimahpv\"<\/p>\n

 <\/p>\n

\n

Bibliography<\/p>\n

1 Genital HPV Infection \u2013 CDC Fact Sheet. http:\/\/www.cdc.gv.\/std\/hpv\/hpv-factsheet-march-2014-press.pdf.Published 2014. Accessed August 24, 2015.
\n2 Tinelli A, et al. HPV viral activity by mRNA HPV molecular analysis to screen the transforming infections in precancer cervical lesions. Curr Pharm Biotechnol<\/em>. 2009;10(8):767-771
\n3 Cuschieri K, et al. Human Papillomavirus Type Specific DNA and RNA Persistence-Implications for Cervical Disease Progression and Monitoring. J Med Virol<\/em>. 2004;73(1):65-70.
\n4 Wright C, et al. The ATHENA human papillomavirus study: design, methods & baseline results. Am J Obstet Gynecol<\/em>. 2012;206(1):46.e1-46.e11 (Study included cobas\u00ae HPV, Hybrid Capture\u00ae 2 assay)
\n5 Aptima HPV Assay (package insert, AW-11141-001 Rev 003 (EN)), San Diego, CA; Hologic, Inc., 2015. Table \u226022.
\n6 De Sanjose, Lancet Oncol<\/em>. 2010;11:1048-56.
\n7 Wheeler CM, et al. J Natl Cancer Institute<\/em> 2009;101:475-487
\n8 Coutlee F, et al. J.Med.Virol<\/em>. 2011;83:1034-1041
\n9 Morris, Clin Chem Lab Med<\/em> 2005; 43(11):1171-1177<\/p><\/blockquote>\n

\n","protected":false},"excerpt":{"rendered":"

Aptima HPV Test for high risk types and Aptima HPV 16 18\/45 detect the presence of an active HPV infection, which may cause cervical cancer.\u00a0\u00a0Almost all women and men will come in contact with the virus at some point in their life. However, very few will suffer from the infection or will have cancer 1.\u00a0Aptima […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1575","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/pages\/1575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/comments?post=1575"}],"version-history":[{"count":0,"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/pages\/1575\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.womansprevention.gr\/en\/wp-json\/wp\/v2\/media?parent=1575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}